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Clinical trials (using the Wegovy formulation) have shown that when combined with lifestyle changes, non-diabetic participants lost about 12-13 percentage points more body weight compared to those taking a placebo over 68 weeks
Administered as a once-weekly subcutaneous injection, tirzepatide works by enhancing insulin secretion in response to elevated blood glucose levels, suppressing glucagon release, slowing gastric emptying, and reducing appetite
Its use was limited to type 2 diabetes
doi:10.1007/s00228-015-1832-0 37
Shaha C, Suri A, Talwar GP (1990) Induction of infertility in female rats after active immunization with 24 kD antigens from rat testes
